Many people pursue greatness, wealth and fame at the cost of everything in their lives. They will sacrifice all their time, their families, their vacations, many hours of needed rest, and even neglect their health to become great, or add to their financial portfolio. The problem with pursuing things that rust and rot: In the end, what did any of those pursuits earn you? Maybe they earned you a few years in the limelight - a few better possessions (for a few years - but no time to enjoy them) - or recognition by your peers (which is fast-fleeting in the grave)!
You can clearly see my opinion of seeking after things that fail to satisfy, or securing an eternal relationship with God, that will help you make a lasting difference in people's lives. Like fools gold, many earthly pursuits look better on the surface, than they prove to be when you examine their true worth.
The sacrifice that God desires, and that really will make a difference in your life: Walking in obedience to God, and pursuing Him with your whole life. We know this is true, because the Bible declares this truth repeatedly. One excellent example is found in 1 Samuel 15:22, where God makes this truth clear to us; 'But Samuel replied: "Does the LORD delight in burnt offerings and sacrifices as much as in obeying the voice of the LORD? To obey is better than sacrifice, and to heed is better than the fat of rams."
You can spend your life in the pursuit of pleasure, wealth or fame - but in the end - you will come up empty-handed, like Solomon, who during the closing days of his life made this observation about his earthly pursuits, "Worthless, worthless, all is worthless."
Or you can be like Samuel, the "wailing prophet" - who loved seeking God from a young age, who had an exemplary, strong relationship with God, and became a man that God used to change generations. He learned to make right choices, and firmly set the greatest value upon the Lord, not the things of this world.
In Matthew 6, Jesus taught us what really matters in life. I hope you take time to read that chapter for yourself. But to summarize this chapter, He taught us to believe God for all we need, and clearly defined needs. Note: A summer house on the lake, expensive cars, bigger rings, more toys, and larger stock options are not needs. They fall into the category of wants. There is a difference, remember that.
What we 'really' need: clothes on our back, food to sustain us, and a home to shelter us from the elements (like the birds of the air). Nothing more in the natural sphere, is actually 'needed' to sustain us.
Then Jesus spoke to the spiritual part of our being - to reveal to our hearts what pursuits are really the most important of all. "But seek ye first the kingdom of God, and His righteousness, and all these things will be added unto you."
In other words, if you put God first, He will supply your needs. Make a mental note: There's no comparison - pursuing God is more important than chasing after the fast-fleeting desires of the flesh!
Think of it this way. Even if you amassed a fortune greater than Bill Gates or Warren Buffett - how long would you be in possession of it? A few decades at best, right? And what then? Which of your earthly possessions has the power to sustain you through eternity? And which ones helped transform the lives of others for God? None of them. Only the relationship that you firmly establish between you and God will be worth the cost of your investment, in the end.
The choice is yours! But remember - you only get one shot at life. Make the right choice early and often, and the end results will make God, you, and many others rejoice at the end results! Simple. Really.